LINUS October 1996

CD-ROM Highlights

OSH CD

Betty Lam, Medical Library

OSH CD is produced by the Health and Safety Commission and the Health and Safety Executive. The publications referenced in OSH CD are either published by these two organizations or by HMSO.

OSH CD includes Occupational Safety and Health legislation, statutory instruments, guidance, advice, re ports and newletters from the UK British Health and Safety Executive. It covers the information from the pre- and post- 1974 Health and Safety at Work Act. OSH CD also includes:

• European Community directives and other legislation on health and safety issues.
• Chemical Hazard Information and Packaging (CHIP).
  This is the approved list of databases from the UK Health and Safety Executive which currently contains risk and safety labelling information on more than 1,500 hazardous chemicals.
• British Standards with abstracts from over 1,500 standards relevant to health and safety.

The publications in OSH-CD fall into 9 main groups.

J

Journals

R

Research

T

Translations

B

Bibliographies

S

Standards

E

EU legislation

L

UK legislation

I

Interpretations of the legislation

G

Guidance and Advice

Information not included:

• Certificates of exemption
• Certificates of approval
• Posters
• Films and videos
• Floppy disks
• Forms used in conjunction with legislation
  Note: the actual list of forms is included as a document

Special Search Features

Search for OSH CD documents by using:

1. Group (GP) field or
2. Database Table of Contents which has both browse and search mode.

Within each of the nine groups in the Table of Contents there are three subgroup levels, the last one being the list of the actual records. In order to view the next subgroup level, one has to use the Expand menu choice.

Sample record from OSH-CD

Eg. Search for Hazardous-waste

TI: The extracellular expression of oncogene products, and their relevance to the monitoring of occupational toxic infults.

CA: Health and Safety Executive, Research and Laboratory Services Division, Occupational Medicine and Hygiene Laboratory.

AU: A.E. Scobbie (Scobbie-A-E)

PB: [1991]

PY: 1991

SE: Research and Laboratory Services Division (RLSD) Reports. Biochemistry Section; IR-L-BI-91-01

NT: Distribution
Dr J.G. Firth, Dr. N.G. Nest, ...
Authorised by: Dr. Hik Wilson
Date issued: May 1991
AVAILABLE TO ANYONE. PERMISSION TO QUOTE FROM THIS DOCUMENT IN A PUBLICATION MUST BE OBTAINED THROUGH THE AUTHORISING OFFICER.

PROJECT NO: S80.06

GP: R-Research

SC: RIS Health-and-Safety-Laboratory-Reports

UD: 199409

AN: 06082

ABSTRACT

Occupational exposure to certain classes of chemicals has been shown to induce changes in DNA Structure (Brand Bauf, 1990). These changes (mutations) at specific DNA sequences may ultimately lead to the development of malignancy in specific organs or tissues of the body...

INTRODUCTION

It has been suspected for many years that alteration in DNA is a central step in the process of cellular transformation and oncogenesis...

ONCOGENES

The initial identification of oncogenes occurred through the analysis of viruses which caused tumours in various animal systems. The RNA tumour viruses, now known as retroviruses, were among the first recognised...

The Biochemical Functions of Oncoproteins...

The Ras Oncogene and its P21 Protein

One of the most critical findings in oncogene research was the discovery that a single gene from the DNA of a human bladder carcinoma (the EJ gene) could maglignantly transfer NIH 3T3 cells in culture upon transfection of the gene into cells (Reddy et al, 1982; Tabin et al, 1982)..

Monitoring of the Expression of Oncogene Encoded Proteins...

SUMMARY...

REFERENCES...

Bratt-Rauf P.W. et al. (1989) The Journal of the Society of Occupational Medicine 39, 141-143. Serum oncogene protein in hazardous waste workers...

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